Dowling-Degos disease is characterized by a lacy or net-like reticulate pattern of abnormally dark skin coloring hyperpigmentation , particularly in the body's folds and creases. These skin changes typically first appear in the armpits and groin area and can later spread to other skin folds such as the crook of the elbow and back of the knee. Less commonly, pigmentation changes can also occur on the wrist, back of the hand, face, scalp, scrotum in males , and vulva in females. Individuals with Dowling-Degos disease may also have dark lesions on the face and back that resemble blackheads, red bumps around the mouth that resemble acne, or depressed or pitted scars on the face similar to acne scars but with no history of acne. Cysts within the hair follicle pilar cysts may develop, most commonly on the scalp.
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Itin PH, Burger B. Spontaneous fading of reticular pigmentation in Naegeli-Franceschetti-Jadassohn syndrome. Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: two allelic ectodermal dysplasias caused by dominant mutations in KRT Fifty-four novel mutations in the NF1 gene and integrated analyses of the mutations that modulate splicing.
Int J Mol Med ; Millikan LE. Adapalene: an update on newer comparative studies between the various retinoids. Int J of Dermatol ; Dermatol Surg ; Full text How to cite this article. Key words: Dowling-Degos disease, keratin 5, protein O-fucosyltransferase 1, protein O-glucosyltransferase 1, Galli-Galli disease.
Dermatology Online Journal
Key words:. Enfermedad de Dowling-Degos. Dermatol Rev Mex ; Enfermedad de Dowling- Degos. Actas Dermosifiliogr ;
2014, Number 6
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Dowling-Degos disease DDD or reticular pigmented anomaly of the flexures is a rare autosomal dominant genodermatosis with variable penetrance. It mainly affects young women and is characterized by acquired reticular hyperpigmentation of the large skin folds. View PDF.
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