BETA OXIDACION PEROXISOMAL PDF

Written Paper. Beyer, A. Erdmann, R. Lookup at Google Scholar. Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae: molecular analysis of the fox2 gene and gene product. Hiltunen, J.

Author:Majora Faugor
Country:Trinidad & Tobago
Language:English (Spanish)
Genre:Medical
Published (Last):27 October 2011
Pages:397
PDF File Size:15.51 Mb
ePub File Size:8.54 Mb
ISBN:725-6-43990-996-1
Downloads:40639
Price:Free* [*Free Regsitration Required]
Uploader:Magore



Hepatocyte oxidant stress and alcoholic liver disease. Conde de la Rosa, H. Moshage 1 y N. Palabras clave: Apoptosis. Muerte celular. Acute and chronic alcohol consumption increases the production of reactive oxygen species ROS , and enhances lipid peroxidation of lipids, proteins, and DNA. The mechanism by which alcohol causes cell injury is still not clear but a major role for ROS and lipid peroxidation-end products is considered.

Many pathways have been suggested to play a role on how ethanol induces a state of "oxidative stress", including redox-state changes, acetaldehyde production, damage to mitochondria, membrane injury, apoptosis, ethanol-induced hypoxia, effects on the immune system and altered cytokine production, increased endotoxin levels and activation of Kupffer cells, mobilization of iron, modulation of the antioxidant defense, particularly mitochondrial glutathione GSH , one electron oxidation of ethanol to 1-hydroxy-ethyl radical, and induction of CYP2E1.

These pathways are not exclusive of one another and it is likely that several, indeed many, systems contribute to the ability of ethanol to induce a state of oxidative stress. Key words: Apoptosis. Cell death. Alcoholic liver disease. Reactive oxygen species. Algunas de estas especies por ejemplo, O 2. En condiciones normales, el O 2. Genera O 2. Las tres isoformas dismutan el O 2. Los hepatocitos expresan Fas CD95 pero no ligando Fas.

La familia de la PI3-cinasa es una superfamilia que comprende tres clases distintas de enzimas vinculadas con la supervivencia celular. Se han descrito tres isoformas distintas de la HO Tumour necrosis factor related apoptosis inducing ligand TRAIL induces hepatic steatosis in viral hepatitis and after alcohol intake.

Gut ; 54 11 : Reuben A. Alcohol and the liver. Curr Opin Gastroenterol ; 23 3 : Managing the complications of cirrhosis. Mayo Clin Proc ; 75 5 : Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin Liver Dis ; 27 1 : Lieber CS. Alcoholic fatty liver: Its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol ; 34 1 : Molecular pathogenesis of alcohol-induced hepatic fibrosis.

Alcohol Clin Exp Res ; 29 11 Supl. Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier. Hepatol Res ; 33 2 : Cederbaum AI. Iron and CYP2E1-dependent oxidative stress and toxicity.

Alcohol ; 30 2 : Oxidative stress: Role of mitochondria and protection by glutathione. Biofactors ; 8 : J Hepatol ; 44 5 : Loguercio C, Federico A. Oxidative stress in viral and alcoholic hepatitis. Free Radic Biol Med ; 34 1 : Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P 2E1-derived reactive oxygen species. Hepatol ; 35 1 : J Biol Chem ; 14 : Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide.

Hepatol ; 38 1 : Reid AE. Nonalcoholic steatohepatitis. Gastroenterol ; 3 : Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein.

Gastroenterol ; 2 : Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: Characterization and mechanism. J Lipid Res ; 42 1 : Mitochondria and microsomal membranes have a free radical reductase activity that prevents chromanoxyl radical accumulation. Biochem Biophys Res Commun ; 1 : Mitochondrial electron transport-linked tocopheroxyl radical reduction. J Biol Chem ; 36 : The oxidation of ubiquinol by the isolated Rieske iron-sulfur protein in solution.

Arch Biochem Biophys ; 2 : Trumpower BL. New concepts on the role of ubiquinone in the mitochondrial respiratory chain. J Bioenerg Biomembr ; 13 : Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

J Bioenerg Biomembr ; 38 1 : Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J ; 3 : Uric acid and oxidative stress.

Curr Pharm Des ; 11 32 : J Biol Chem ; 32 : Heme oxygenase-1 protects HepG2 cells against cytochrome P 2E1-dependent toxicity. Free Radic Biol Med ; 36 3 : Cytochrome P 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit. Hepatology ; 37 1 : Cytochrome P 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells.

J Biol Chem ; 12 : CYP2E1-dependent toxicity and up-regulation of antioxidant genes. J Biomed Sci ; 8 1 : Lu Y, Cederbaum AI. Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P 2E1. Toxicol Sci ; 89 2 : Datta NJ, Namasivayam A. In vitro effect of methanol on folate-deficient rat hepatocytes. Drug Alcohol Depend ; 71 1 : Gastroenterol ; 4 : Molecular organization of peroxisomal enzymes: Protein-protein interactions in the membrane and in the matrix.

Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Free Radic Biol Med ; 33 3 : Marked differences in the efficacy of post-insult gene therapy with catalase versus glutathione peroxidase. Brain Res ; 1 : Hepatic mitochondrial glutathione: Transport and role in disease and toxicity. Toxicol Appl Pharmacol ; 3 : Nieto N.

CARBOLINE BITUMASTIC 300M PDF

Beta oxidation

In biochemistry and metabolism , beta-oxidation is the catabolic process by which fatty acid molecules are broken down [1] in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA , which enters the citric acid cycle , and NADH and FADH 2 , which are co-enzymes used in the electron transport chain. It is named as such because the beta carbon of the fatty acid undergoes oxidation to a carbonyl group. Beta-oxidation is primarily facilitated by the mitochondrial trifunctional protein , an enzyme complex associated with the inner mitochondrial membrane , although very long chain fatty acids are oxidized in peroxisomes. Free fatty acids cannot penetrate any biological membrane due to their negative charge. Free fatty acids must cross the cell membrane through specific transport proteins , such as the SLC27 family fatty acid transport protein. Once the fatty acid is inside the mitochondrial matrix , beta-oxidation occurs by cleaving two carbons every cycle to form acetyl-CoA. The process consists of 4 steps.

EUROSET 815 S MANUAL PDF

.

FDF FILE NOT POPULATING PDF

.

Related Articles