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Chronic Myeloide Leukemia: natural history and classification. Chiattone II. CML is a clonal disease characterized by balanced translocation between chromosomes 9 and 22 Philadelphia chromosome. The disease is characterized by a triphasic course that includes a chronic phase CP , an accelerated phase AP and an acute or blastic phase BP. Unless the disease is controlled or eliminated, patients progress to AP and BF in variable periods of time. Several staging classification systems are used for CML all of which were designed in the pre-imatinib era.

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Chronic Myeloide Leukemia: natural history and classification. Chiattone II. CML is a clonal disease characterized by balanced translocation between chromosomes 9 and 22 Philadelphia chromosome. The disease is characterized by a triphasic course that includes a chronic phase CP , an accelerated phase AP and an acute or blastic phase BP.

Unless the disease is controlled or eliminated, patients progress to AP and BF in variable periods of time.

Several staging classification systems are used for CML all of which were designed in the pre-imatinib era. In this article we discuss the natural history of CML and phase definitions according to the most useful criteria.

Key words: CML; classification; staging; prognostic factors; disease progression. De fato, o conceito de FA tem mudado desde que os estudos dessas drogas se iniciaram.

Chronic myeloid leukemia: current application of cytogenetics and molecular testing for diagnosis and treatment. Mayo Clin Proc. Bortolheiro TC. Therapy of chronic myeloid leukemia with imatinib mesylate in Brazil: study of 98 cases. Clinical heterogeneity in chronic myeloid leukemia refleting biological diversity in normal persons.

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Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia: high incidence of early complete and major cytogenetic responses. The biology of chronic myelogenous leukemia: implications for imatinib therapy.

Semin hematol. Thiele J, Kvasnicka HM. A critical reappraisal of the WHO classification of the chronic myeloproliferative disorders. Leuk Lymphoma. The molecular biology of chronic myeloid leukemia. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. Survival benefit with imatinib mesylate therapy in patients with accelerated-phase chronic myelogenous leukemia-comparison with historic experience.

The degree of bone marrow fibrosis in chronic myelogenous leukemia is not a prognostic factor with imatinib mesylate therapy. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. Como citar este artigo.

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Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed. Its annual incidence has been estimated at between 1 and 1. The majority of patients are diagnosed in the chronic phase and may be either asymptomatic diagnosed through a routine white blood cell count or present with fatigue, anaemia, weight loss, night sweats or splenomegaly. CML is characterised by the presence of the Philadelphia chromosome, an abnormality resulting from a balanced translocation between chromosomes 9 and 22 t 9;22 q34;q CML does not appear to be an inherited disease and the factors leading to predisposition for the disorder remain largely unknown.

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