Abstract: Pseudobulbar affect PBA is a common manifestation of brain pathology associated with many neurological diseases, including amyotrophic lateral sclerosis, Alzheimers disease, stroke, multiple sclerosis, Parkinsons disease, and traumatic brain injury. PBA is defined by involuntary and uncontrollable expressed emotion that is exaggerated and inappropriate, and also incongruent with the underlying emotional state. However, because concentrations of dextrorphan which is responsible for many of the parent drugs side effects and quinidine are lower than those observed in clinical practice with these drugs administered alone, some of the perceived safety issues may not be as relevant with this low dose combination product. Pseudobulbar affect PBA , also called pathological laughing and crying PLC , is a common manifestation of brain pathology. The terms used to describe this abnormally expressed emotion have varied over the years, including disinhibition, affective lability, emotional dysregulation, and involuntary emotional expression disorder. PLC is defined as involuntary and uncontrollable expressed emotion laughing or crying or both that is exaggerated relative to the stimulus as well as the experienced emotion.
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It can happen in people with a brain injury or certain neurologic conditions. Pseudobulbar affect: an under-recognized and under-treated neurological disorder. Adv Ther. These are not all of the diagnostic features of depression or PBA. PBA is a real condition that you can do something about. Ask your doctor how PBA can be managed. Answer these questions, then talk to your doctor about your options. Remember: PBA is different from depression, but it's possible to have both at the same time.
The two should be diagnosed and managed separately. Other names are sometimes used to describe PBA. Many of these don't accurately describe the condition or its symptoms.
You may hear others refer to PBA as:. Skip to main content. It's different from depression. It's possible to have PBA and depression at the same time, but the two are separate conditions that should be diagnosed and managed separately. Find out more. Underlying Condition. You also have a neurologic condition or brain injury. You may or may not have a neurologic condition or brain injury. Crying is part of your depression that can last weeks or months. It can be frustrating, because you're not sad, despite how it looks.
Or things aren't as funny as they may seem. Because PBA symptoms always happen as a result of another neurologic condition or brain injury, they can feel like yet another difficulty to deal with. Pseudobulbar affect: burden of illness in the USA. Embarrassment from the Situation. Personal Discouragement. Wondering if you or someone you love might have PBA?
Need help explaining your symptoms to your doctor? Get tips for starting the conversation.
It can happen in people with a brain injury or certain neurologic conditions. Pseudobulbar affect: an under-recognized and under-treated neurological disorder. Adv Ther. These are not all of the diagnostic features of depression or PBA. PBA is a real condition that you can do something about. Ask your doctor how PBA can be managed.
Afecto Pseudobulbar, Dextrometorfan y Quinidina
PBA occurs secondary to a neurologic disorder or brain injury. Patients may find themselves crying uncontrollably at something that is only moderately sad, being unable to stop themselves for several minutes. Episodes may also be mood-incongruent : a patient may laugh uncontrollably when angry or frustrated, for example. Sometimes, the episodes may switch between emotional states, resulting in the patient crying uncontrollably before dissolving into fits of laughter.